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Title: Role Of Lumbar Sympathetic Block In Linezolid Induced Peripheral Neuropathy With Lower Limb Motor Dysfunction.
e-poster Number: INSIM76
Category: Pain
Author Name: Rutvi Mody
Institute: Pain Clinic of India
Co-Author Name: Dr. Prakash Deshmukh, Dr. Manjiri Ranade, Dr. Kailash Kothari, Dr. Yogita Bhargude
Abstract :
Background and Aims: Linezolid is a class- A drug of multi drug resistant and extensively drug resistant TB. Linezolid use carries a considerable risk of toxicity, with the optimal dose and duration remaining unclear. We have seen 75 patients with confirmed linezolid induced peripheral neuropathy, out of which 5 patients showed decreased great toe power in both lower limbs, which improved on treatment with bilateral lumbar sympathetic block. This case series aims to describe the findings of these patients and to provide hypothesis for the use of sympathetic block in Linezolid induced peripheral neuropathy patients who have developed motor dysfunction.
Method: 5 patients, who were diagnosed with Linezolid induced peripheral neuropathy of lower limb, gave history of ‘slipping of chappals’ when asked and on examination there was decreased great toe power(4/5) in both lower limbs. All 5 patients underwent bilateral lumbar sympathetic block.
Result: All patients reported immediate relief of symptoms after procedure. On examination great toe power was 5/5 in all 5 patients.
Conclusion: Lumbar sympathetic block looks to be promising treatment for Linezolid induced peripheral neuropathy patients who have developed motor dysfunction in lower limbs.
