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Title: TPS (Transcranial Pulse Stimulation) Treatment Of Alzheimer'S Disease Is Increasingly Successful
e-poster Number: INSIM26
Category: Neurology
Author Name: Pavel Novak
Institute: Storz Medical AG
Co-Author Name: Gabriela Novak
Abstract :
Low intensity shockwaves proofed to be efficient for the treatment of non-unions, tendon and muscular pain, wound healing, heart insufficiency, erectile dysfunction, aesthetic since 1990. The working principle is the mechanical stimulation of biological processes called mechanotransduction. Transcranial Pulse Stimulation TPS) uses shockwave pulses for mechanical stimulation of the brain tissue.
Alzheimer’s disease patients have been treated with TPS since 2010. The treatment consists of a booster block of 6 treatment sessions within 2 weeks and one re-treatment session per month after the initial 3 months. 6000 shockwave pulses with energy flux density of 0.2mJ/mm2 are applied in one session.
The CERAD score is improved by 10-17% within the first 3 months. The long-term data exists for more than 3 years. The results to date show that the monthly re-treatment is sufficient for maintaining the improvement for at least one year. Thereafter, dependent on patient’s disease progress it might be necessary to repeat the initial booster block of 6 sessions in 2 weeks. Meanwhile there are over 100 clinical sites using this method (Neurolith, Storz Medical AG) resulting in over 1000 treated patients with more than 10’000 treatment sessions. The treatment is very well accepted, with satisfaction rate of up to 80%. It is safe and effective. There have been no relevant negative side effect observed.
The regulatory clearance in Europe is based on two center clinical trial with 35 patients. In spite of the successful clinical applications further scientific data are needed. There are placebo controlled clinical trials ongoing.
